The Latvian has handed the world No.4 her earliest loss at Roland Garros since 2016.
Simona Halep will take on Amanda Anisimova at the French Open again after a serene 6-3 6-4 victory over Irina-Camelia Begu.
Kiki Bertens came through her match against Sara Errani but left the court on a wheelchair.
The decision was made by the 23-time Grand Slam winner shortly after a warm-up.
Sofia Kenin battles past Samsonova to reach the second round at Roland Garros.
The lackluster Czech overcame some patchy play to set up a showdown with a former French Open champion in the next round.
On the eve of the doubles draw one team has been removed following a positive test.
The multiple Grand Slam winner opens up about her mental demons.
Garbine Muguruza outlasted Tamara Zidansek 7-5 4-6 8-6 to book her place in the second round of the 2020 French Open.
Elina Svitolina fought hard to overcome Varvara Gracheva in a tricky first-round encounter at the 2020 French Open.
Serena Williams had a tough test in her opening match at Roland Garros.
Petra Kvitova sealed her place in the second round with a strong win over Oceane Dodin.
The American veteran ends 2020 with just one recorded win on the WTA Tour in eight tournaments played.
The world No.2 reacts to her opening win at Roland Garros.
The women's seeds kicked-off their Roland Garros bid with straight-sets wins but voiced their concerns about the conditions in Paris shortly afterwards.
The clay court major has had its first controversy less than an hour after getting underway.
The Czech has less than a week to recover from a thigh problem before the next Grand Slam gets underway.
The world No.2 has won the Italian Open in unfortunate circumstances.
The 24-year-old is still winning trophies but this time it isn't in tennis.
The Romanian is hoping that it will be third time lucky at the Foro Italico this year.