Novak Djokovic could face Stan Wawrinka in his clay court opener in Monte Carlo after the draw was made for the Masters 1000 event.
The Serb is in the top half of the draw and is the third seed in the tournament where he resides and is a potential quarter-final for Alex De Minaur.
Before facing De Minaur, the two-time champion could be set to face Stan Wawrinka in his opening match should the Swiss beat Alejandro Tabilo.
Heading into the potential match Djokovic leads the head-to-head 21-6 and should he reach the third round would face Grigor Dimitrov.
Another blockbuster match in this section of the draw will see ninth seed Daniil Medvedev take on Karen Khachanov.
In the top quarter of the draw Alexander Zverev will aim to get his season back on track when he takes on either a qualifier or Matteo Berrettini in his opening match.
A third round match against Jiri Lehecka or Lorenzo Musetti could await before facing sixth seed Stefanos Tsitsipas in the last eight.
Tsitsipas could face Holger Rune in the third round in what is a fascinating section of the draw.
In the third quarter of the draw Jack Draper and Casper Ruud could be set to meet in the quarter-finals.
Indian Wells champion Draper will face either Marcos Giron or Denis Shapovalov in the opening round while Ruud will take on Roberto Bautista Agut or Brandon Nakashima.
Rounding up the draw is second seed Carlos Alcaraz who looks finally set to play Monte-Carlo after missing the last two years.
The Spaniard will play Fabio Fognini or Francisco Cerundolo in his opener before facing Felix Auger-Aliassime in the third round.
Here is the full draw with play starting on Monday:
