Former US Open finalist Madison Keys suffered a disappointing defeat at the hands of world number 51 Anhelina Kalinina.
The Ukrainian put aside the war-torn turmoil back home, to win 3-6, 6-3, 6-4 and move into the last 32 at the Miami Open.
Keys continues to demonstrate a mixed bag of form.
On the one hand, she has impressed this season in winning in Adelaide. As well as reaching the semi-finals of the Australian Open and the quarter-finals last week at Indian Wells.
In both scenarios, she lost to the eventual winner, Ash Barty and Iga Świątek, respectively.
But the American went out at the first hurdle in both Mexico tournaments, Guadalajara and Monterrey.
Now the 27-year-old’s attentions turn to the clay-court season where she could start off in Andalucía, Spain, or Charleston, United States.
Other notable results in the women’s draw saw Spain’s Paula Badosa ease past Marie Bouzková 7-5, 7-5 on GrandStand.
Her opponent in the last 32 will be Kazakhstan’s Yulia Putintseva, who beat Ukraine’s Lesia Tsurenko; 6-3, 4-6, 7-5.
American’s Jessica Pegula and Coco Gauff also advanced with straight sets wins over Sloane Stephens and Wang Qiang, respectively.
And teenager Linda Fruhvirtova stunned Elise Mertens; 7-5, 2-6, 6-1.
In the men’s, a huge shock saw 2018 champion John Isner beaten by French youngster Hugo Gaston; 7-6 (7-5), 6-4.
Four years ago, the American stood at the pinnacle of his career, winning a first Masters 1000 title, after coming back from a set down to defeat Alexander Zverev.
But he was harshly brought back down to earth by the talented Gaston.
Having been as high as world number eight that same year, the 36-year-old’s season continues to stutter.
Isner, must now regroup quickly with the clay-court season fast approaching, and a good performance again in Monte Carlo will surely be top of his wish list.
Elsewhere in the men’s draw, Spain’s Pablo Carreño Busta comfortably beat Belgium’s David Goffin in straight sets, 6-3, 6-2.
And there were mixed fortunes again for American tennis, as qualifier Dennis Kudla overcame the 19th seed Lorenzo Sonego of Italy; 3-6, 7-6 (7-5), 6-4.
But Reilly Opelka was forced to concede due to injury after only winning two games and trailing 6-1, 3-1 to Argentina’s Francisco Cerúndolo.
He faces Frenchman Gaël Monfils next.
