All round of 16 matches will be played on Thursday, with 47 Major singles titles represented. There is some rain forecast early in the day, but skies should clear by mid-afternoon, allowing all action to be completed. And with fans on the grounds for the first time this week, there will be a whole different energy at Foro Italico.
Men’s round of 16 action features two matchups where top 10 seeds collide. Overall, seven of the top 10 men in the world are still alive in this draw. That includes Rafael Nadal and Novak Djokovic, who have combined to win this event 14 out of the last 16 years.
On the women’s side, four French Open champions remain. One of them is Garbine Muguruza, who will take on two-time Rome champion Elina Svitolina. The other three (Ash Barty, Iga Swiatek, and Jelena Ostapenko) all face unseeded yet challenging competition on Thursday.
Throughout the tournament, this preview will analyze the day’s two most prominent matches, while highlighting the other notable matches on the schedule. Thursday’s play begins at 10:00am local time.
Stefanos Tsitsipas (5) vs. Matteo Berrettini (9) – Not Before 12:00pm on Grand Stand Arena
This matchup was scheduled to take place in February at the Australian Open, but Berrettini was forced to withdraw from the tournament due to an abdominal injury. The 25-year-old Italian would miss nearly two months of action, though he’s now 10-2 since returning. Matteo was the champion in Belgrade and the runner-up in Madrid, so he’s played a lot of tennis over the last few weeks.
Tsitsipas has been busy as well, with an 11-2 record during the European clay swing. Like Matteo, he earned one title and reached the final of another event (Monte-Carlo and Barcelona, respectively). They did play at the Australian Open two years ago, when Stefanos claimed a tight four-setter. They also met in qualifying for the 2017 US Open, with Tsitsipas winning in a third-set tiebreak. Stefanos’ form this past month on clay has been stellar. And between this week and the last, he’s played significantly less tennis than Matteo. Despite Berrettini’s hometown crowd rooting him on, Tsitsipas should advance.
Elina Svitolina (5) vs. Garbine Mugruza (12) – Not Before 6:00pm on Center Court
Svitolina won back-to-back titles here in 2017 and 2018. Yet outside of those runs, she’s just 4-5 lifetime in Rome. On Wednesday, Elina recovered from a tough opening set to defeat Amanda Anisimova in three. Muguruza has reached three semifinals in Rome, though is yet to advance farther. She too was forced to come from behind on Wednesday. Garbine was down two breaks in the third set, when American Bernarda Pera tightened up, allowing Muguruza to take that set 7-5.
This will be the tenth meeting in their rivalry, which Svitolina leads 6-3 at tour level. However, they’ve split their two clay court matches. In 2021, Muguruza has been the better player. She has accumulated a 23-6 record, with one title and two runner-up trophies. Svitolina is 18-8 on the season, though she’s yet to reach a final. And against the top 20, she’s just 2-4, with her only two wins coming against Petra Kvitova. Muguruza did have to withdraw from Madrid last week due to a thigh injury. But if she’s feeling close to 100%, Garbine is the favorite based on her recent form.
Other Notable Matches on Thursday:
Novak Djokovic (1) vs. Alejandro Davidovich Fokina (Q) – Djokovic has never lost before the quarterfinals in Rome, but could be challenged by the 21-year-old Spaniard, who is 10-5 on clay this season. This is their first career meeting.
Ash Barty (1) vs. Veronika Kudermetova – Barty advanced comfortably on Wednesday despite some strapping on her leg. 24-year-old Kudermetova is an impressive 24-10 in 2021, and was a champion last month on the green clay of Charleston. This is also their first meeting.
Rafael Nadal (2) vs. Denis Shapovalov (13) – Denis’ exciting win over Rafa at 2017’s Rogers Cup was his breakout moment, but he’s 0-2 against Nadal since that time. Shapovalov was a semifinalist in Rome last September, while Nadal has failed to reach the quarterfinals here only once in 16 appearances.
Angelique Kerber vs. Jelena Ostapenko – Their only head-to-head matchup was a significant one. In the 2018 Wimbledon semifinals, Kerber prevailed 6-3, 6-3 on her way to the title. Neither player has won three consecutive matches this year, a feat one of them will achieve on Thursday.
Andrey Rublev (7) vs. Roberto Bautista Agut (10) – They have split six previous encounters, though Rublev has claimed both their matches on clay, including last month in Monte-Carlo.
Aryna Sabalenka (7) vs. Coco Gauff – Sabalena is on a seven-match win streak, and is 11-1 on clay this season. Gauff has already survived two three-setters this week. They met twice last year, with each claiming one victory, and each match going the distance.
Sascha Zverev (6) vs. Kei Nishikori – Sascha and Kei just played last week in Madrid, with Zverev winning 6-3, 6-2. That victory started Zverev’s current six-match win streak. Like fellow Madrid champion Sabalenka, he’s only dropped one set during that time.
Iga Swiatek (15) vs. Barbora Krejcikova – The reigning French Open champ has won 11 of her last 12 matches on clay. Swiatek defeated Krejickova in straight sets earlier this year in Miami.
Dominic Thiem (4) vs. Lorenzo Sonego – Thiem came back from a set down on Wednesday against Marton Fucsovics, while Sonego took out Gael Monfils in the last round. When they met on clay in 2019, Thiem prevailed in straights.
Karolina Pliskova (9) vs. Vera Zvonareva (Q) – On Wednesday, Zvonareva upset another big-hitting Czech, Petra Kvitova. Pliskova was the champion here two years ago, and the runner-up last season. Three years ago in Moscow, Zvonareva dominated Pliskova, allowing her only three games.
Thursday’s full Order of Play is here.

