Novak Djokovic will start his bid for a fourth US Open title against Damir Dzumhir while Alexander Zverev has been handed a difficult opening round match at Flushing Meadows.
The Serb will look to take advantage of the fact that Rafael Nadal and Roger Federer are absent from this year’s tournament, as he chases a fourth US Open champion.
Djokovic, who has yet to lose a match this season, will begin his campaign against Damir Dzumhur in what is a comfortable quarter of the draw for the top seed.
Kyle Edmund could await in the second round, should he beat Alexander Bublik and then matches against Jan-Lennard Struff, John Isner and David Goffin could await the Serb on his way to the semi-finals.
In the other quarter of the top half of the draw, Alexander Zverev has a dangerous opening round match as he takes on 2017 finalist Kevin Anderson.
Adrian Mannarino and Jack Sock are potential last 32 matches for the German should he get that far as Diego Schwartzman and Hubert Hurkacz are also waiting in this section of the draw.
A potential last eight match could be 4th seed Stefanos Tsitsipas, who will play Albert Ramos-Vinolas in the first round.
Tsitsipas could then face Borna Coric in the third round before a last 16 clash with Cristian Garin.
In the bottom half of the draw. last year’s finalist Daniil Medvedev will open up his campaign against Federico Delbonis.
Medvedev, who lost to Nadal in five sets last year, has a favourable section of the draw with his toughest coming against Grigor Dimitrov in the fourth round.
Dimitrov, who had COVID-19 a couple of months ago, will play Tommy Paul in R1 and possibly come up against Nikoloz Basilashvili in the last 32.
Matteo Berrettini is a potential last eight match-up for Dimitrov or Medvedev. The Italian’s toughest opponent is expected to be Andrey Rublev in round four, although he has Jeremy Chardy awaiting in the first match of the week.
The final quarter of the draw sees Dominic Thiem and Roberto Bautista Agut feature but both have stern challenges awaiting them in their path to the quarter-finals.
Thiem, who reached the Australian Open final in January, begins with Jaume Munar with Marin Cilic potentially awaiting in R3.
Felix Auger-Aliassime is another obstacle awaiting for the Austrian but the Canadian could have to overcome Brits Andy Murray and Dan Evans in consecutive matches to set up a showdown with Thiem.
As for Bautista Agut, he begins with Tennys Sandgren while the in-form Milos Raonic and Karen Khachanov could await in later rounds.
Here is the draw for the men’s singles, with play starts on Monday:
